Human immune toxicity

Abstract

This review examines xenobiotic toxicity to the immune system, stressing in particular those aspects of most relevance to humans. Immunotoxicity is examined especially from three points of view: by what immunological component is affected, by classes of foreign agents that adversely affect the human immune system and by critical evaluation of human case reports and epidemics. Mechanisms by which xenobiotics interrupt cytokine networks are emphasized. The concept that microbial agents, both environmental as well as infectious, may act as immunotoxicants, either alone or in synergism with conventional agents is introduced. Instances of human immunotoxicology are critically evaluated in terms of clinical relevance, i.e. whether increased susceptibility to opportunistic infections or tumor emergence takes place in the affected individuals.