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. 1993 Aug;20(11):1516-9.

[Arterial infusion chemotherapy of 5-FU and leucovorin for patients with liver metastases from colorectal cancer]

[Article in Japanese]
T Yamamura  1 , A Hanai, H Oikawa, H Matsuzaki, K Kikuchi, O Akaishi, K Seo, T Ozasa, K Katayama
Affiliations
  • PMID: 8373209

[Arterial infusion chemotherapy of 5-FU and leucovorin for patients with liver metastases from colorectal cancer]

[Article in Japanese]
T Yamamura et al. Gan To Kagaku Ryoho. 1993 Aug.

Abstract

Fifteen patients with liver metastases from colorectal cancer were treated by arterial infusion of 5-FU and leucovorin. Two regimens were performed. One was weekly bolus infusion of leucovorin following bolus infusion of 5-FU (bolus group), the other was 5 days continuous infusion of 5-FU and leucovorin in 3 weeks (continuous group). One PR was obtained both in the bolus group and in the continuous groups. The objective response rate was 11% in the bolus group and 20% in the continuous group. The one- and 2-year survival rates for these patients were 40% and 0% in the bolus group, and 80% and 60% in the continuous group, respectively. These results suggest that continuous arterial infusion of 5-FU and leucovorin was more effective than individual bolus arterial infusion of leucovorin and 5-FU for patients with liver metastases from colorectal cancer.

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