Synthesis, antibacterial and antifungal activity of metal (II) complexes of 2-acetylpyridine thiosemicarbazones
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- PMID: 8373503
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Synthesis, antibacterial and antifungal activity of metal (II) complexes of 2-acetylpyridine thiosemicarbazones
Farmaco.
1993 Jun.
Abstract
2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2- methylthiosemicarbazone) and their metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal (II) complexes exhibited significant activity against a wide spectrum of microorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most active compounds.
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