Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1993 Oct 1;72(7):2234-8.
doi: 10.1002/1097-0142(19931001)72:7<2234::aid-cncr2820720728>3.0.co;2-n.

A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis

L K Rocke  1 , C L Loprinzi, J K Lee, S J Kunselman, R K Iverson, G Finck, D Lifsey, K C Glaw, B A Stevens, A K Hatfield, et al.
Affiliations
Clinical Trial

A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis

L K Rocke et al. Cancer. .

Abstract

Background: The authors previously reported that 30 minutes of oral cryotherapy inhibits 5-fluorouracil (5-FU)-induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection.

Methods: This trial involved patients who were receiving their first course of a 5-FU plus leucovorin chemotherapy regimen, for which stomatitis is a major dose-limiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5-FU therapy.

Results: A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis.

Conclusion: The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5-FU-based chemotherapy.

PubMed Disclaimer

Publication types