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Case Reports
. 1993 Aug;69(1):35-7.
doi: 10.1016/0165-4608(93)90109-y.

Deletion of chromosome 13 in osteosarcoma secondary to irradiation

Y Y Ozisik  1 , A M Meloni, M M Zalupski, J R Ryan, F Qureshi, A A Sandberg
Affiliations
Case Reports

Deletion of chromosome 13 in osteosarcoma secondary to irradiation

Y Y Ozisik et al. Cancer Genet Cytogenet. 1993 Aug.

Abstract

The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.

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