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Review
. 1993 Jun;12(2):73-82.
doi: 10.1007/BF00689802.

The experimental development of bioreductive drugs and their role in cancer therapy

P Workman  1 , I J Stratford
Affiliations
Review

The experimental development of bioreductive drugs and their role in cancer therapy

P Workman et al. Cancer Metastasis Rev. 1993 Jun.

Abstract

Bioreductive drugs undergo metabolic reduction to generate cytotoxic metabolites. This process is facilitated by bioreductive enzymes and the lower oxygen conditions present in solid tumours compared to normal tissues. Because of this specificity, bioreductive drugs have enormous potential to contribute to modern cancer therapy. Examples undergoing clinical trials include N-oxides such as tirapazamine, aziridinylnitroimidazoles RSU 1069/RBU 6145 and quinones such as indoloquinone EO9. Other novel structures are also under study. Here we review the experimental development of bioreductive drugs and their role in cancer therapy.

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