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Case Reports
. 1993 Aug;24(8):923-7.
doi: 10.1016/0046-8177(93)90145-7.

Lineage-restricted chromosome translocation in a benign fibrous tumor of the breast

F Belda  1 , S C Lester, J L Pinkus, G S Pinkus, J A Fletcher
Affiliations
Case Reports

Lineage-restricted chromosome translocation in a benign fibrous tumor of the breast

F Belda et al. Hum Pathol. 1993 Aug.

Abstract

We describe a clonal chromosome rearrangement, t(4;14)(q24-25;q24.3), in a benign fibrous tumor of the breast. This is the first reported cytogenetic analysis of a fibrous tumor of the breast and the first evidence for clonality in these lesions. A combined immunohistochemical/cytogenetic study demonstrated that cells with the clonal translocation were mesenchymal. Epithelial cells, in contrast, had normal chromosomes.

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