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. 1993 Jul 23;617(1):105-10.
doi: 10.1016/0378-4347(93)80427-6.

Simultaneous high-performance liquid chromatographic determination of lornoxicam and its 5'-hydroxy metabolite in human plasma using electrochemical detection

T Suwa  1 , H Urano, Y Shinohara, J Kokatsu
Affiliations

Simultaneous high-performance liquid chromatographic determination of lornoxicam and its 5'-hydroxy metabolite in human plasma using electrochemical detection

T Suwa et al. J Chromatogr. .

Abstract

A selective and sensitive high-performance liquid chromatographic method with coulometric detection is described for the simultaneous quantitation of lornoxicam, a new oxicam class drug, and its 5'-hydroxy metabolite in human plasma. The two analytes and the internal standard are extracted from plasma at pH 4.0 by liquid-liquid extraction and separated on a C18 column. Absolute detection limits using 100 microliters of plasma are found to be 5 and 10 ng/ml for lornoxicam and 5'-hydroxylornoxicam, respectively. The assay described has been successfully applied to samples from clinical studies.

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