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Review
. 1993 Jul;9(7):246-9.
doi: 10.1016/0168-9525(93)90089-z.

Mutagenesis by 8-oxoguanine: an enemy within

A P Grollman  1 , M Moriya
Affiliations
Review

Mutagenesis by 8-oxoguanine: an enemy within

A P Grollman et al. Trends Genet. 1993 Jul.

Abstract

The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.

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