The rubro-bulbospinal path. A descending system known to influence dynamic fusimotor neurones and its interaction with distal cutaneous afferents in the control of flexor reflex afferent pathways

Abstract

The inhibitory effect of electrical stimulation in the near-rubral region on polysynaptic segmental as well as ascending pathways activated by the flexor reflex afferents (FRA) in hind limb nerves was studied in chloralose anaesthetized cats. The effective stimulating region totally coincided with the one from which a D zone climbing fibre response may be elicited in the contralateral cerebellar cortex. The descending path was dependent upon an intact dorsolateral spinal funiculus, where also a characteristic volley could be recorded with a surface electrode on short train central stimulation. The suppressive action on the transmission through the FRA pathways was evoked in the absence of a lower lumbar dorsal root potential, and it was concluded that the effect was exerted by postsynaptic inhibition. It was suggested that this descending path, the effects of which resemble those elicited from the dorsal reticulospinal system, is identical to the rubro-bulbospinal path, previously known to influence dynamic fusimotor neurones. The transmission through the FRA pathways was also suppressed by conditioning stimulation of ipsilateral, low threshold distal cutaneous afferents. The time course of this effect was the same as that with central conditioning stimulation. Facilitatory interaction was revealed with double conditioning and it was suggested that the descending path and the distal cutaneous afferents converge upon a common group of interneurones, which postsynaptically inhibit an early (possibly the first one) interneurone in the FRA pathways. As low threshold distal cutaneous afferents supply the primary peripheral input via climbing fibres to the cerebello-cortical D zone, it was concluded that the different stimuli (central or peripheral) which activate a common group of inferior olivary neurones destined for the D zone also activate a common group of segmental inhibitory interneurones. The results are discussed in relation to current concepts of segmental motor control, and it is suggested that the mechanisms studied could be involved in the regulation of stepping.