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. 1993 Jan 1;53(1):1-4.

Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer

Y Horio  1 , T Takahashi, T Kuroishi, K Hibi, M Suyama, T Niimi, K Shimokata, K Yamakawa, Y Nakamura, R Ueda, et al.
Affiliations
  • PMID: 8380124

Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer

Y Horio et al. Cancer Res. .

Abstract

We evaluated the prognostic significance of p53 mutations and an allelic loss of chromosome 3p in 71 patients with non-small cell lung cancer who underwent potentially curative resection. p53 mutations were detected in 35 cases (49%), while 3p deletions were observed in 34 of 70 informative cases (49%). The presence of the p53 mutation was associated with a shortened survival in all patients (P = 0.014 by log rank test), including those in early stages of the disease (stage I or II, n = 48) (P = 0.016 by log rank test). Multivariate analysis by the Cox proportional hazards model also revealed that p53 mutation was an independent yet unfavorable prognostic factor (P = 0.013). Patients with 3p deletion tended to have a poorer prognosis, but not to a statistically significant extent.

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