doi: 10.1016/0014-2999(93)90809-v.
Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release
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- PMID: 8380771
- DOI: 10.1016/0014-2999(93)90809-v
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Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release
Eur J Pharmacol.
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Abstract
Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 microM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.
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