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. 1993 Jan-Feb;14(1):77-87.

Extirpation of glioblastomas: MR and CT follow-up of residual tumor and regrowth patterns

M Forsting  1 , F K Albert, S Kunze, H P Adams, D Zenner, K Sartor
Affiliations

Extirpation of glioblastomas: MR and CT follow-up of residual tumor and regrowth patterns

M Forsting et al. AJNR Am J Neuroradiol. 1993 Jan-Feb.

Abstract

Purpose: To optimize the timing of CT and MR after glioblastoma resection and to define the pattern of tumor regrowth.

Subjects and methods: Sixty-eight patients with glioblastoma were studied prospectively with CT and MR. The first postoperative scan was obtained between day 1 and day 5; follow-up scans were obtained bimonthly.

Results: Residual tumor was shown most reliably on scans obtained shortly after surgery (MR, 77%; CT, 40.5%). After the fourth day up to 3 months postoperatively, surgically induced enhancement prevented recognition of residual tumor. Seventy-five percent of patients with residual tumor shown by early postoperative MR had progressive disease during follow-up, whereas only 36% of patients without evidence of residual tumor had MR signs of progressive disease.

Conclusion: Early, enhanced, postoperative MR is the radiologic procedure of choice to determine the extent of glioblastoma resection. Gross total tumor resection as determined by early postoperative MR correlates with a prolongation of life.

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