Effects of intravenous secretin and cholecystokinin on gallbladder net water absorption and motility in the cat

Abstract

A perfusion technique has been used for the simultaneous study of the concentrating mechanism and the motility of the gallbladder in the anesthetized cat. It was found that intravenous secretin abolished the net water absorption from bile in the gallbladder and thereby impeded its concentrating mechanism, but alone did not influence gallbladder motility. It was sometimes seen that secretin even reversed the net water transport in the gallbladder, producing a secretion. Intravenous cholecystokinin was found not to influence the net water transport but to induce a strong contraction of the gallbladder. These results are discussed in relation to those from earlier in vitro studies.