The role of some polar amino acid residues in secretin
- PMID: 838239
Item in Clipboard
The role of some polar amino acid residues in secretin
Gastroenterology.
1977 Apr.
Abstract
Three analogues of S5-27, the tricosapeptide with the carboxyl-terminal sequence of secretin, were studied. In the analogues, the acidic residues at positions 9 and 15 of S5-27 were replaced by the neutral residues glutamine and asparagine. These changes resulted in a decrease in immunoreactivity. Binding to an antibody against secretin could be correlated with the changes in the conformation of the synthetic analogues.
Similar articles
-
Superior immunoreactivity of 125I (Des-Tyr-betaAla)-secretin with rabbit anti-secretin sera compared to 125I-secretin and 125 I-6-Tyrosyl secretin.Horm Metab Res. 1976 Nov;8(6):459-61. doi: 10.1055/s-0028-1093595. Horm Metab Res. 1976. PMID: 1002105
-
Immunological aspects of secretin, substance P, and VIP.Gastroenterology. 1977 Apr;72(4 Pt.2):803-10. Gastroenterology. 1977. PMID: 838240
-
A re-examination of the conformation of secretin in water.Clin Endocrinol (Oxf). 1976;5 Suppl:195S-200S. doi: 10.1111/j.1365-2265.1976.tb03827.x. Clin Endocrinol (Oxf). 1976. PMID: 1052778
-
Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.J Pharmacol Exp Ther. 1996 Nov;279(2):555-60. J Pharmacol Exp Ther. 1996. PMID: 8930157
-
Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.Biochem Soc Trans. 2007 Aug;35(Pt 4):709-12. doi: 10.1042/BST0350709. Biochem Soc Trans. 2007. PMID: 17635130 Review.
Cited by
-
Radioimmunoassay of secretin. A critical review and current status.Dig Dis Sci. 1980 Jul;25(7):529-52. doi: 10.1007/BF01315215. Dig Dis Sci. 1980. PMID: 6104568 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
