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Comparative Study
. 1993 Feb;22(1):41-51.
doi: 10.3109/08820139309066192.

HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus

C Caruso  1 , G Candore, A T Colucci, D Cigna, F Sammartano, P Ammatuna
Affiliations
Comparative Study

HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus

C Caruso et al. Immunol Invest. 1993 Feb.

Abstract

Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-B8,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-B8,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-B8,DR3 negative ones. These results further strengthen the suggestion that HLA-B8,DR3 positive subjects are low responders and that the depth of immune response depends on the fashion of antigenic challenge.

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