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. 1993 Jan:31 Suppl A:23-8.
doi: 10.1093/jac/31.suppl_a.23.

Susceptibility survey of piperacillin alone and in the presence of tazobactam

J F Acar  1 , F W Goldstein, M D Kitzis
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Susceptibility survey of piperacillin alone and in the presence of tazobactam

J F Acar et al. J Antimicrob Chemother. 1993 Jan.

Abstract

Among 325 fresh isolates of bacteria from 153 hospital patients with serious infections, 142 were susceptible to piperacillin, 129 were resistant and a further 54 exhibited a marked inoculum effect. Tazobactam restored the susceptibility of resistant isolates of Staphylococcus aureus and Staphylococcus epidermidis (except methicillin-resistant isolates), Haemophilus influenzae, Moraxella catarrhalis, Acinetobacter spp. and Bacteroides fragilis. Among 87 Enterobacteriaceae that were resistant to piperacillin, or showed an inoculum effect, 78 (89%) were restored to susceptibility by tazobactam. Pseudomonas spp. resistant to piperacillin were mostly resistant to the combination.

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