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. 1993;119(6):355-9.
doi: 10.1007/BF01208845.

Low-dose radiation therapy for testicular intraepithelial neoplasia

K P Dieckmann  1 , A Besserer, V Loy
Affiliations

Low-dose radiation therapy for testicular intraepithelial neoplasia

K P Dieckmann et al. J Cancer Res Clin Oncol. 1993.

Abstract

Four patients with unilateral testicular germ-cell tumor and biopsy-proven contralateral testicular intraepithelial neoplasia (TIN; so-called carcinoma in situ) received localized low-dose radiation therapy (18-20 Gy) of the testis with TIN. Repeated biopsies disclosed the disappearance of TIN and germ cells. No recurrence of TIN or germ cells was observed after a follow-up of 18-42 months. All patients reported a normal sex life without need of androgen supplementation. Serum follicle-stimulating hormone increased significantly immediately after radiation treatment and started to decline after 24 months. Serum luteinizing hormone increased slightly but not significantly. A decline after 24 months was observed in only one of three patients. Serum testosterone decreased significantly in all patients after 1 year but never became subnormal. Low-dose radiation treatment is efficacious in eradicating testicular intraepithelial neoplasia without destroying Leydig cells or stromal cells of the testis. Thus, a patient otherwise destined to develop a second testicular tumor can be spared orchiectomy and life-long hormonal replacement.

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References

    1. Cameron KM, Pugh RCB (1976) Effects of radiation. In: Pugh, RCB (ed) Pathology of the testis. Blackwell, Oxford, pp 457–459
    1. Dieckmann K-P, Loy V (1991) Persistent testicular intraepithelial neoplasia after chemotherapy. Eur Urol 20:258–260 - PubMed
    1. Dieckmann K-P, Loy V, Huland H (1989) Das Carcinoma in situ des Hodens: klinische Bedeutung, Diagnose und Therapie. Urologe [A] 28:271–280 - PubMed
    1. Dieckmann K-P, Loy V, Büttner P (1993) Prevalence of bilateral testicular germ cell tumours and early detection based on contralateral testicular intraepithelial neoplasia. Br J Urol (in press) - PubMed
    1. Fleck H, Stahl F, Mau S (1981) Untersuchungen über die Ausschaltung der testikulären Testosteronproduktion durch Hodenbestrahlung bei Patienten mit Prostatakarzinom. Z Urol Nephrol 74:443–446 - PubMed

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