Comparative Study
doi: 10.1006/viro.1993.1221.
The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts
Affiliations
- PMID: 8384744
- DOI: 10.1006/viro.1993.1221
Item in Clipboard
Comparative Study
The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts
Virology.
1993 Apr.
Abstract
The virion host shutoff function (VHS) of many herpesviruses is required for inhibition of cellular gene expression in infected cells. This function corresponds to the UL41 open reading frame of herpes simplex virus type 1 (HSV-1) and homolog sequences have been found in other alphaherpesvirus, like HSV-2, Varicella-Zoster virus (VZV) and equine herpesvirus type 1 (EHV-1). In this work, we have cloned and sequenced a pseudorabies virus (PRV) gene which is homologous to the VHS genes of the other alphaherpesvirus. Sequence comparison between all deduced amino acid sequences indicates the presence of several conserved domains, separated by regions containing gaps or low conserved sequences.
Similar articles
-
ICP22 homolog of equine herpesvirus 1: expression from early and late promoters.J Virol. 1992 Feb;66(2):664-73. doi: 10.1128/JVI.66.2.664-673.1992. J Virol. 1992. PMID: 1370553 Free PMC article.
-
Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster.J Virol. 1995 Sep;69(9):5560-7. doi: 10.1128/JVI.69.9.5560-5567.1995. J Virol. 1995. PMID: 7637001 Free PMC article.
-
The equine herpesvirus type 1 (EHV-1) homolog of herpes simplex virus type 1 US9 and the nature of a major deletion within the unique short segment of the EHV-1 KyA strain genome.Virology. 1992 Sep;190(1):307-15. doi: 10.1016/0042-6822(92)91217-i. Virology. 1992. PMID: 1326805
-
Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1.Vet Microbiol. 1996 Nov;53(1-2):67-77. doi: 10.1016/s0378-1135(96)01235-7. Vet Microbiol. 1996. PMID: 9010999 Review.
-
The genome of herpes simplex virus: structure, replication and evolution.J Cell Sci Suppl. 1987;7:67-94. doi: 10.1242/jcs.1987.supplement_7.6. J Cell Sci Suppl. 1987. PMID: 2846596 Review.
Cited by
-
The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virions.J Virol. 2002 Jul;76(13):6729-42. doi: 10.1128/jvi.76.13.6729-6742.2002. J Virol. 2002. PMID: 12050386 Free PMC article.
-
mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.J Virol. 2002 Sep;76(17):8560-71. doi: 10.1128/jvi.76.17.8560-8571.2002. J Virol. 2002. PMID: 12163576 Free PMC article.
-
Regulation of the vhs gene promoter of pseudorabies virus by IE180 and EP0, and the requirement of a Sp1 Site for the promoter function.Virus Genes. 2004 Apr;28(3):247-58. doi: 10.1023/b:viru.0000025772.67359.f8. Virus Genes. 2004. PMID: 15266106
-
The amino terminus of the herpes simplex virus 1 protein Vhs mediates membrane association and tegument incorporation.J Virol. 2006 Oct;80(20):10117-27. doi: 10.1128/JVI.00744-06. J Virol. 2006. PMID: 17005689 Free PMC article.
-
Characterization of strain HSZP of herpes simplex virus type 1 (HSV1).Folia Microbiol (Praha). 1999;44(6):713-9. doi: 10.1007/BF02825668. Folia Microbiol (Praha). 1999. PMID: 11097032
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
