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Review
. 1993 Feb;51(2):380-5.

[Hepatocarcinogenesis in terms of HGF and its receptor]

[Article in Japanese]
H Kanda  1 , T Kitagawa
Affiliations
  • PMID: 8385239
Review

[Hepatocarcinogenesis in terms of HGF and its receptor]

[Article in Japanese]
H Kanda et al. Nihon Rinsho. 1993 Feb.

Abstract

Hepatocyte growth factor (HGF) is a highly potent growth stimulator of hepatocytes and c-met proto-oncogene has recently been identified as its high-affinity receptor. Since the c-met gene expression is found in many types of cells, carcinogenic and/or transforming activity through autocline or paracline mechanism of HGF-c-met/HGFR system has become point of interest. By transfecting HGF into a unique immortalized mouse hepatocytes (MLE-10), which expresses c-met at high level, we were able to first demonstrate transforming activity of HGF by autocline mechanism.

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