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. 1993 Jun;6(6):587-91.

Clinical significance of HIV DNA in polymorphonuclear neutrophils from patients with HIV infection

D I Gabrilovich  1 , V Vassilev, V V Nosikov, L V Serebrovskaya, L A Ivanova, V V Pokrovsky
Affiliations
  • PMID: 8388451

Clinical significance of HIV DNA in polymorphonuclear neutrophils from patients with HIV infection

D I Gabrilovich et al. J Acquir Immune Defic Syndr (1988). 1993 Jun.

Abstract

HIV DNA was detected by the polymerase chain reaction technique in polymorphonuclear neutrophils (PMNs) in 11 of 37 (29.7%) HIV-infected patients. A detectable level of HIV DNA in PMNs was more common in symptomatic than asymptomatic HIV infected patients (46.7% and 18.2%, respectively; p < 0.05). HIV DNA in PMNs was detected most frequently in patients with recurrent bacterial pneumonia or Pneumocystis carininii pneumonia. An association between HIV DNA in PMNs and a low CD4/8 ratio as well as high levels of immunoglobulins in the sera was noted. Detectable HIV DNA was found more frequently in patients with neutropenia than in those with a normal level of neutrophils in peripheral blood (44.4% and 28.0%, respectively; p < 0.05). These data suggest that infection of PMNs by HIV may be associated with PMN impairment during HIV infection.

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