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. 1993 Feb;182 ( Pt 1)(Pt 1):105-8.

Experimental galactose neuropathy: quantitative changes in intramembranous particles in fracture faces of the perineurium

N G Beamish  1 , C Stolinski, P K Thomas, R H King
Affiliations

Experimental galactose neuropathy: quantitative changes in intramembranous particles in fracture faces of the perineurium

N G Beamish et al. J Anat. 1993 Feb.

Abstract

Peripheral nerves in rats fed a diet containing 40% galactose develop endoneurial oedema related to the accumulation of interstitial galactitol and sodium. Biochemical studies of the perineurium in galactose neuropathy indicate an increase in membrane bound Na+/K(+)-ATPase activity. The present study has analysed the intramembraneous particles (IMPs) on the P membrane fracture faces of the perineurium in galactose-fed rats and has demonstrated a significant increase in the density of IMPs. This finding may reflect changes in the perineurial cell membranes in galactose neuropathy, such as increased membrane bound Na+/K(+)-ATPase activity.

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