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. 1993 Jul;67(7):4399-403.
doi: 10.1128/JVI.67.7.4399-4403.1993.

Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus

S Carpenter  1 , S A Nadin-Davis, Y Wannemuehler, J A Roth
Affiliations

Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus

S Carpenter et al. J Virol. 1993 Jul.

Abstract

Transient expression assays using the reporter gene that encodes chloramphenicol acetyltransferase were used to identify cis-acting sequences necessary for bovine immunodeficiency-like virus (BIV) transactivation. Computer analyses identified two RNA stem-loop structures located immediately downstream of the transcription start site in the long terminal repeat. Deletion analysis of the long terminal repeat indicated that sequences containing the proximal stem-loop structure located between +4 and +31 are required for virus-specific transactivation. Therefore, BIV likely utilizes a mechanism of transactivation similar to that of the human and simian lentiviruses.

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