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. 1993 Jun 25;1173(3):353-6.
doi: 10.1016/0167-4781(93)90138-4.

Molecular cloning and expression of a rat cDNA encoding MDCK-type chloride channel

T Abe  1 , K Takeuchi, K Ishii, K Abe
Affiliations

Molecular cloning and expression of a rat cDNA encoding MDCK-type chloride channel

T Abe et al. Biochim Biophys Acta. .

Abstract

A cDNA encoding MDCK-type chloride channel was cloned from the rat kidney cDNA library using the homology screening approach. The deduced amino acid sequence of cloned cDNA has a 92.4% homology with the MDCK chloride channel, and electrophysiological analysis using Xenopus oocyte expression system showed the functional character of chloride channel. The rat kidney chloride channel, abbreviated RKCL, is not specific to the kidney, but widely expressed in various tissues. It is suggested that RKCL is important for most cells.

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