Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Aug 1;90(15):7225-9.
doi: 10.1073/pnas.90.15.7225.

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice

T Lufkin  1 , D Lohnes, M Mark, A Dierich, P Gorry, M P Gaub, M LeMeur, P Chambon
Affiliations

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice

T Lufkin et al. Proc Natl Acad Sci U S A. .

Abstract

Retinoic acid (RA) plays a critical role in normal development, growth, and maintenance of certain tissues. The action of RA is thought to be mediated in part by the three nuclear receptors (RAR alpha, -beta, and -gamma), each of which is expressed as multiple isoforms. To investigate the function of the RAR alpha gene, we have disrupted, in the mouse, the whole gene or the isoform RAR alpha 1. Although RAR alpha 1 is the predominant isoform and is highly conserved among vertebrates, RAR alpha 1-null mice appeared normal. However, targeted disruption of the whole RAR alpha gene resulted in early postnatal lethality and testis degeneration. These results, showing that RAR alpha is indeed involved in the transduction of the RA signal, also suggest an unexpected genetic redundancy.

PubMed Disclaimer

References

    1. Cell. 1992 Oct 2;71(1):73-85 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10138-42 - PubMed
    1. Curr Top Dev Biol. 1992;27:309-50 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9065-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2700-4 - PubMed

Publication types