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Comparative Study
. 1993 Jul;31(7):1774-6.
doi: 10.1128/jcm.31.7.1774-1776.1993.

Herpes simplex virus detection from genital lesions: a comparative study using antigen detection (HerpChek) and culture

R W Cone  1 , P D Swenson, A C Hobson, M Remington, L Corey
Affiliations
Comparative Study

Herpes simplex virus detection from genital lesions: a comparative study using antigen detection (HerpChek) and culture

R W Cone et al. J Clin Microbiol. 1993 Jul.

Abstract

The sensitivity of a rapid enzyme immunoassay test (HerpChek Direct Herpes Simplex Virus Antigen Test [DuPont Medical Products, Wilmington, Del.]) for the detection of herpes simplex virus (HSV) antigens in patient specimens was compared with HSV culture. HerpChek positivity for HSV occurred with 179 (65%) of 275 lesion specimens, whereas culture for HSV was positive for 145 (53%) lesions (P = 0.002). HerpChek was twice as sensitive as culture for the detection of HSV in late-stage lesions and was equivalent to culture for the detection of HSV in early lesions. We conclude that HerpChek provides greater sensitivity than culture for HSV detection in late-stage genital lesions.

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