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. 1993 Jul;84(7):726-33.
doi: 10.1111/j.1349-7006.1993.tb02036.x.

Loss of VLA-2 collagen receptor in breast carcinoma, facilitating invasion and metastasis

K Arihiro  1 , K Inai, K Kurihara, S Takeda, M Kaneko, K Kuroi, T Toge
Affiliations

Loss of VLA-2 collagen receptor in breast carcinoma, facilitating invasion and metastasis

K Arihiro et al. Jpn J Cancer Res. 1993 Jul.

Abstract

The integrin VLA-2 as a collagen receptor and VLA-5 as a fibronectin receptor were detected immunohistochemically in normal, benign tumor and carcinoma tissues of the breast. Both proteins were also detected by Western-blot analysis in some carcinoma cases. Epithelial and myoepithelial cells of both normal breast and benign tumor were in all cases immunoreactive for VLA-2 in the plasma membrane. Carcinoma cells in the invasive component were not immunoreactive for VLA-2 in 31 (46%) of 67 cases. Carcinoma cells in the intraductal components were negative for VLA-2 in only 4 (11%) of 36 cases, while 20 cases (56%) showed weak expression and 12 cases (33%) showed strong expression. Metastatic carcinoma cells in the lymph nodes of 6 cases showed no immunoreactivity except in one case, whereas, again with the exception of one case, the carcinoma cells in the primary tumors did show VLA-2 expression. With regard to VLA-5, there was no difference in its expression in the invasive components and the intraductal components. These findings suggest that the loss of VLA-2 plays a role in the invasion and metastasis of breast carcinoma.

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