Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jul 15;246(2):149-55.
doi: 10.1016/0922-4106(93)90092-n.

Cloning and functional expression of a human parathyroid hormone receptor

H Schneider  1 , J H Feyen, K Seuwen, N R Movva
Affiliations

Cloning and functional expression of a human parathyroid hormone receptor

H Schneider et al. Eur J Pharmacol. .

Abstract

We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids shows high homology to the previously cloned receptors from opossum and rat. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pKD = 8.5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover.

PubMed Disclaimer