Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Oct;168(4):803-9.
doi: 10.1093/infdis/168.4.803.

Sequence variants of human papillomavirus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia

L Ho  1 , S K Tay, S Y Chan, H U Bernard
Affiliations

Sequence variants of human papillomavirus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia

L Ho et al. J Infect Dis. 1993 Oct.

Abstract

Human papillomavirus type 16 (HPV-16) is causally involved in the pathogenesis of genital neoplasia, but important details of the natural history of infection and disease are not yet understood. Many individual HPV-16 DNA isolates differ by characteristic point mutations. In a study of the HPV-16 variants from genital lesions of 32 married couples, HPV-16 was detected in both the husband and the wife in 8 couples. Of these, 4 demonstrated identical HPV-16 variants between husband and wife, and 4 had mismatching HPV-16 variants. Five of 31 biopsies showed simultaneous presence of two different HPV-16 variants. The data suggest that sexual transmission of HPV-16 does occur, but with low infectivity, and that HPV-16-related premalignant lesions are frequently polyclonal.

PubMed Disclaimer

Publication types

MeSH terms