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Review
. 1993 Jun;14(6):243-6.
doi: 10.1016/0167-5699(93)90039-N.

Humanized antibodies

G Winter  1 , W J Harris
Affiliations
Review

Humanized antibodies

G Winter et al. Immunol Today. 1993 Jun.

Erratum in

  • Immunol Today. 2008 Apr;29(4):149

Abstract

Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.

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