Review
doi: 10.1016/0167-5699(93)90039-N.
Humanized antibodies
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- PMID: 8397764
- DOI: 10.1016/0167-5699(93)90039-N
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Review
Humanized antibodies
Immunol Today.
1993 Jun.
Erratum in
- Immunol Today. 2008 Apr;29(4):149
Abstract
Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.
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