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Review
. 1993 Jun;14(6):247-51.
doi: 10.1016/0167-5699(93)90040-R.

The use of monoclonal antibodies to achieve immunological tolerance

H Waldmann  1 , S Cobbold
Affiliations
Review

The use of monoclonal antibodies to achieve immunological tolerance

H Waldmann et al. Immunol Today. 1993 Jun.

Erratum in

  • Immunol Today. 2008 Apr;29(4):149

Abstract

Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.

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