Review
doi: 10.1016/0167-5699(93)90143-9.
The maturation of the immune response
- PMID: 8397779
- DOI: 10.1016/0167-5699(93)90143-9
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Review
The maturation of the immune response
Immunol Today.
1993 Aug.
Erratum in
- Immunol Today 1993 Oct;14(10):479
Abstract
In a T-cell dependent immune response, the repertoire of antigen-activated B cells is diversified by a hypermutation mechanism. Only high-affinity variants are selected into the pool of memory cells. This maturation process takes place in a special micro-environment, the germinal centre. Here, Claudia Berek and Mike Ziegner discuss the mechanisms underlying these processes.
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