Review
doi: 10.1016/0167-5699(93)90144-a.
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
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- PMID: 8397780
- DOI: 10.1016/0167-5699(93)90144-a
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Review
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
Immunol Today.
1993 Aug.
Abstract
Studies of the antibody hypermutation mechanism have revealed that it is not a random process but exhibits characteristic nucleotide substitution preferences. Here, Alexander Betz and colleagues show that these innate nucleotide substitution preferences can be used to examine databases of antigen-selected V gene sequences and thereby distinguish intrinsic from antigen-selected hotspots. This analysis reveals intrinsic mutational hotspots in both VH and VL genes, reflecting innate features of the hypermutation machinery which may give clues to the enzymatic mechanism.
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