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Comparative Study
. 1993 Oct;11(4):703-11.
doi: 10.1016/0896-6273(93)90080-b.

The C. elegans unc-18 gene encodes a protein expressed in motor neurons

K Gengyo-Ando  1 , Y Kamiya, A Yamakawa, K Kodaira, K Nishiwaki, J Miwa, I Hori, R Hosono
Affiliations
Comparative Study

The C. elegans unc-18 gene encodes a protein expressed in motor neurons

K Gengyo-Ando et al. Neuron. 1993 Oct.

Abstract

The C. elegans unc-18 gene is required to maintain normal acetylcholine levels. We determined the complete structure of an unc-18 cDNA that encodes a protein of 591 highly charged and hydrophilic amino acids. The protein shows sequence similarity with elements of the secretory pathway in the yeast S. cerevisiae. Antibodies raised against a portion of the unc-18-encoded protein (UNC-18) detected a 68 kd soluble antigen on immunoblots and intensely stained all vertical cord motor neurons in situ. These findings suggest that UNC-18 participates in the axonal transport system and influences the acetylcholine flow in motor neurons.

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