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. 1993 Oct;68(4):808-12.
doi: 10.1038/bjc.1993.432.

Prognostic impact of EGF-receptor in papillary thyroid carcinoma

L A Akslen  1 , A O Myking, H Salvesen, J E Varhaug
Affiliations
Free PMC article

Prognostic impact of EGF-receptor in papillary thyroid carcinoma

L A Akslen et al. Br J Cancer. 1993 Oct.
Free PMC article

Abstract

In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.

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