doi: 10.1016/0025-5564(93)90028-9.
Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity
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- PMID: 8400580
- DOI: 10.1016/0025-5564(93)90028-9
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Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity
Math Biosci.
1993 Sep-Oct.
Abstract
A stochastic epidemic model is formulated for the study of the protective effects of vaccination in a population that is stratified by vaccine-related factors. The epidemic model is transformed into a counting process, and then martingale-based methods are used to provide estimators of vaccine efficacy and their variances. Following an example, various extensions of the model are discussed.
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