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. 1993 Jul 30;618(1):155-9.
doi: 10.1016/0006-8993(93)90439-t.

Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1 beta during fever

T Nakamori  1 , A Morimoto, K Yamaguchi, T Watanabe, N C Long, N Murakami
Affiliations

Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1 beta during fever

T Nakamori et al. Brain Res. .

Abstract

The present study was carried out to determine whether interleukin-1 (IL-1) production occurs in the rabbit organum vasculosum laminae terminalis (OVLT) during fever induced by endotoxin. The intravenous (i.v.) injection of endotoxin (4 micrograms/kg) caused significant fever in rabbits. Through the use of in situ hybridization and immunohistochemical techniques, the synthesis of IL-1 was observed in the OVLT during the fever. The present results support the hypothesis that IL-1 is produced in the brain during fever.

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