A flow cytometric study of the rat Yoshida AH-130 ascites hepatoma

Abstract

The implantation of the Yoshida AH-130 ascites hepatoma to rats results in a marked reduction in body weight in the tumour-bearing hosts. This is associated with an important reduction in both food intake and energetic efficiency in the last period of tumour growth. The growth of the tumour mass has a clear initial exponential phase, in which the maximum cell density is reached, with the majority of cells being in the synthetic phase (S) followed by most of the cells being in the G0/G1 phase, as determined using flow cytometry.