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Comparative Study
. 1993 Oct 22;75(2):217-27.
doi: 10.1016/0092-8674(93)80064-l.

Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones

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Free article
Comparative Study

Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones

Y Luo et al. Cell. .
Free article

Abstract

Repulsive guidance cues can steer neuronal growth cones during development and prevent mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain that is a good candidate for a repulsive cue. Since it induces the collapse and paralysis of neuronal growth cones in vitro, we have named it collapsin. It is effective at concentrations of approximately 10 pM. The C-terminal half of collapsin contains a single immunoglobulin-like domain and an additional highly basic region. The N-terminal half of collapsin shares significant homology with fasciclin IV, a growth cone guidance protein in grasshopper. Recombinant collapsin causes sensory ganglion growth cones to collapse but not retinal ganglion cell growth cones. We propose that collapsin could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism.

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