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. 1979 Feb 1;149(2):485-94.
doi: 10.1084/jem.149.2.485.

HLA-D region-associated determinants serve as targets for human cell-mediated lysis

C Feighery, P Stastny

HLA-D region-associated determinants serve as targets for human cell-mediated lysis

C Feighery et al. J Exp Med. .

Abstract

Effector cells for cell-mediated lysis (CML) were generated by in vitro culture of lymphocytes from selected donors with X-irradiated cells from unrelated subjects who were HLA-D homozygous and matched to the responders for the antigens of the HLA-A and HLA-B regions. By using chromium labeled monocytes as target cells, cytotoxicity was found to correlate with presence of HLA-D region antigens matching those of the stimulating cells. Such CML reactions apparently directed at products of HLA-D, were inhibited by addition of unlabeled monocytes or B lymphocytes. These unlabeled cells had to be matched for HLA-D with the stimulating cells used to generate the effector populations. The results suggested that products of HLA-D, perhaps the DR antigens, were recognized by cytotoxic lymphocytes.

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