Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1993;44(6):593-5.
doi: 10.1007/BF02440867.

Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations

J Reviriego  1 , L Bertilsson, J A Carrillo, A Llerena, M J Valdivielso, J Benítez
Affiliations
Comparative Study

Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations

J Reviriego et al. Eur J Clin Pharmacol. 1993.

Abstract

We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, healthy Spanish Caucasian subjects, based on the enantiomeric S/R mephenytoin ratio in urine collected 0-8 h and 24-32 h after intake of the racemic drug. Five of the subjects were PM (1.34%, 95% confidence interval 0.18-2.59%), a prevalence lower than in 6 other Caucasian populations, but only significantly lower than in studies in France and Switzerland (P < 0.01). We suggest that this difference might be due to the use of different phenotyping procedures.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Clin Pharmacol Ther. 1991 Jan;49(1):18-23 - PubMed
    1. Eur J Clin Pharmacol. 1990;39(6):533-7 - PubMed
    1. Ther Drug Monit. 1990 Jul;12(4):415-6 - PubMed
    1. J Pharmacol Exp Ther. 1985 Sep;234(3):662-9 - PubMed
    1. Clin Pharmacol Ther. 1989 Apr;45(4):348-55 - PubMed

Publication types

LinkOut - more resources