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. 1993 Oct 11;332(1-2):164-8.
doi: 10.1016/0014-5793(93)80505-o.

Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts

T Motoike  1 , S Bieger, H Wiegandt, K Unsicker
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Free article

Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts

T Motoike et al. FEBS Lett. .
Free article

Abstract

Basic fibroblast growth factor (bFGF/FGF-2) is a strong mitogenic inducer of cultured baby hamster kidney (BHK) cells. When cultured BHK cells were stimulated with FGF-2, phosphatidic acid (PA) was induced within 2 min, peaked at 5 min and gradually decreased. Phospholipase D (PLD) was also mitogenic for cultured BHK cells and this effect was mediated via PA. The possibility that PA induction by FGF-2 is an essential signaling step for BHK cell proliferation is discussed.

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