Review
doi: 10.1254/fpj.102.235.
[The state of the art of gastric antisecretory drugs]
[Article in
Japanese]
Affiliations
- PMID: 8406234
- DOI: 10.1254/fpj.102.235
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Review
[The state of the art of gastric antisecretory drugs]
[Article in
Japanese]
Nihon Yakurigaku Zasshi.
1993 Sep.
Abstract
This review article describes the effect and mechanism of various antisecretory drugs. Both histamine H2-receptor antagonists and gastric proton pump inhibitors are now world-widely used as the first choice for the treatment of acid-related diseases. Because of their potential effectiveness in inhibiting gastric acid secretion, new H2-antagonists and pump inhibitors are under development with the aim of mitigating of the side effects. The local antisecretory effects of FPL-52694, NC-1300-O-3 and ME 3407, which were demonstrated in Heidenhain pouch dogs, will provide clues for the development of new types of antisecretory drugs. Antigastrin drugs are also promising.
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