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. 1993 Nov;61(11):4654-61.
doi: 10.1128/iai.61.11.4654-4661.1993.

The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia

D B Schauer  1 , S Falkow
Affiliations

The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia

D B Schauer et al. Infect Immun. 1993 Nov.

Abstract

Transmissible murine colonic hyperplasia is characterized by proliferation of anchored stem cells in the mucosa of the descending colon of laboratory mice and is caused by Citrobacter freundii biotype 4280. This bacterium produces attaching and effacing lesions in the descending colon prior to the onset of gross hyperplasia. By mutational analysis, the chromosomal eae gene of C. freundii biotype 4280 was shown to be necessary for colonic colonization. Conversely, bacteria cured of a 65-kb plasmid, which was identified in C. freundii biotype 4280, were not attenuated for colonic colonization or for the induction of colonic hyperplasia.

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References

    1. Infect Immun. 1991 Nov;59(11):3869-75 - PubMed
    1. Cancer Res. 1979 Jan;39(1):24-9 - PubMed
    1. Science. 1991 Nov 1;254(5032):710-3 - PubMed
    1. Mol Microbiol. 1992 Nov;6(22):3427-37 - PubMed
    1. Infect Immun. 1983 Sep;41(3):1340-51 - PubMed

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