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. 1993 Nov;61(11):4937-9.
doi: 10.1128/iai.61.11.4937-4939.1993.

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

A G Bean  1 , R A Freiberg, S Andrade, S Menon, A Zlotnik
Affiliations

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

A G Bean et al. Infect Immun. 1993 Nov.

Abstract

We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.

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