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. 1993 Oct:74 ( Pt 10):2269-73.
doi: 10.1099/0022-1317-74-10-2269.

Herpes simplex virus type 1 capsid protein, VP21, originates within the UL26 open reading frame

S Person  1 , S Laquerre, P Desai, J Hempel
Affiliations

Herpes simplex virus type 1 capsid protein, VP21, originates within the UL26 open reading frame

S Person et al. J Gen Virol. 1993 Oct.

Abstract

The goal of experiments reported here was to identify the genes that encode capsid proteins VP21 and VP24 of herpes simplex virus type 1 (HSV-1). Capsids were isolated from infected cells and the proteins were separated by SDS-PAGE. N-terminal amino acid sequence analysis of partial CNBr digestion products, and of intact VP21, showed that it is encoded within the UL26 open reading frame (ORF) of HSV-1 beginning with codon 248 and probably extending to the end of the ORF (codon 635). Similar analysis of digestion products confirmed that VP24 is specified by codons 1 to 247 at the 5' end of the UL26 ORF. Each of the seven known capsid proteins has now been assigned to an ORF.

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