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Comparative Study
. 1977 Jan;13(1):107-14.
doi: 10.1016/0090-6980(77)90047-8.

Effect of high concentrations of non-steroidal and steroidal antiinflammatory drugs on prostaglandin-induced contractions of the guinea-pig isolated ileum

J P Famaey, J Fontaine, J Reuse
Comparative Study

Effect of high concentrations of non-steroidal and steroidal antiinflammatory drugs on prostaglandin-induced contractions of the guinea-pig isolated ileum

J P Famaey et al. Prostaglandins. 1977 Jan.

Abstract

In addition to their well-known effect at low concentrations on prostaglandin synthesis or their release and production, 11 non-steroidal antiinflammatory drugs and 4 antiinflammatory steroids exhibit at high concentrations a direct antagonism on certain prostaglandin actions. This is demonstrated on PGE1- and PGF2alpha-induced contractions of guinea-pig isolated ileum when compared to acetylcholine-induced contractions. This inhibitory effect is totally reversible after washing out the drugs from the organ bath.

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