Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Nov;67(11):6551-7.
doi: 10.1128/JVI.67.11.6551-6557.1993.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2

J P Adamczewski  1 , J V Gannon, T Hunt
Affiliations

Simian virus 40 large T antigen associates with cyclin A and p33cdk2

J P Adamczewski et al. J Virol. 1993 Nov.

Abstract

In this paper we provide evidence that a fraction of large T antigen of simian virus 40 (SV40) interacts with cyclin A and p33cdk2 in both virus-infected and stably transformed cells. Immunoprecipitates of SV40 large T antigen from SV40-infected or SV40 large-T-antigen-transformed cells contain cyclin A, p33cdk2, and histone H1 kinase activity. Conversely, immunoprecipitates of cyclin A from these cells contain SV40 large T antigen. In this respect, SV40 large T antigen has properties similar to those of the E1A oncogene of adenoviruses and the E7 oncogene of human papillomaviruses.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1966 Aug;56(2):736-40 - PubMed
    1. Mol Biol Cell. 1992 Nov;3(11):1279-94 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Feb;76(2):610-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2610-4 - PubMed
    1. J Virol. 1981 Sep;39(3):861-9 - PubMed

Publication types

LinkOut - more resources