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. 1993 Nov;67(11):6847-52.
doi: 10.1128/JVI.67.11.6847-6852.1993.

Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

J M Bergelson  1 , N St John, S Kawaguchi, M Chan, H Stubdal, J Modlin, R W Finberg
Affiliations

Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

J M Bergelson et al. J Virol. 1993 Nov.

Abstract

Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.

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