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. 1977 Jan;16(1):155-8.

Paraquat toxicity and pulmonary superoxide dismutase: an enzymic deficiency of lung microsomes

M R Montgomery
  • PMID: 841176

Paraquat toxicity and pulmonary superoxide dismutase: an enzymic deficiency of lung microsomes

M R Montgomery. Res Commun Chem Pathol Pharmacol. 1977 Jan.

Abstract

Paraquat stimulates the microsomal generation of superoxide radical, O2-, and hydrogen peroxide, H2O2. The detoxification of these two oxidants is accomplished by superoxide dismutase (SOD) and catalase, respectively. SOD activity could not be detected in lung microsomes but was found in microsomes of both kidney and liver. This deficiency may be involved in the pulmonary specificity of paraquat.

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